A Critical Examination of Subgroup Analyses: The National Acute Spinal Cord Injury Studies and Beyond

The use of high-dose methylprednisolone for acute spinal cord injury continues to be a topic of debate. This controversy largely stems from fundamental issues in statistical interpretation of trial data, most notably subgroup analyses. The purpose of this review is to discuss important examples of i...

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Detalles Bibliográficos
Autores principales: Hextrum, Shannon, Bennett, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799288/
https://www.ncbi.nlm.nih.gov/pubmed/29449826
http://dx.doi.org/10.3389/fneur.2018.00011
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author Hextrum, Shannon
Bennett, Stephanie
author_facet Hextrum, Shannon
Bennett, Stephanie
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description The use of high-dose methylprednisolone for acute spinal cord injury continues to be a topic of debate. This controversy largely stems from fundamental issues in statistical interpretation of trial data, most notably subgroup analyses. The purpose of this review is to discuss important examples of improper subgroup analysis and encourage better practices in future research.
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spelling pubmed-57992882018-02-15 A Critical Examination of Subgroup Analyses: The National Acute Spinal Cord Injury Studies and Beyond Hextrum, Shannon Bennett, Stephanie Front Neurol Neuroscience The use of high-dose methylprednisolone for acute spinal cord injury continues to be a topic of debate. This controversy largely stems from fundamental issues in statistical interpretation of trial data, most notably subgroup analyses. The purpose of this review is to discuss important examples of improper subgroup analysis and encourage better practices in future research. Frontiers Media S.A. 2018-02-01 /pmc/articles/PMC5799288/ /pubmed/29449826 http://dx.doi.org/10.3389/fneur.2018.00011 Text en Copyright © 2018 Hextrum and Bennett. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hextrum, Shannon
Bennett, Stephanie
A Critical Examination of Subgroup Analyses: The National Acute Spinal Cord Injury Studies and Beyond
title A Critical Examination of Subgroup Analyses: The National Acute Spinal Cord Injury Studies and Beyond
title_full A Critical Examination of Subgroup Analyses: The National Acute Spinal Cord Injury Studies and Beyond
title_fullStr A Critical Examination of Subgroup Analyses: The National Acute Spinal Cord Injury Studies and Beyond
title_full_unstemmed A Critical Examination of Subgroup Analyses: The National Acute Spinal Cord Injury Studies and Beyond
title_short A Critical Examination of Subgroup Analyses: The National Acute Spinal Cord Injury Studies and Beyond
title_sort critical examination of subgroup analyses: the national acute spinal cord injury studies and beyond
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799288/
https://www.ncbi.nlm.nih.gov/pubmed/29449826
http://dx.doi.org/10.3389/fneur.2018.00011
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