Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems

The release of aromatic amines from drugs and other xenobiotics resulting from the hydrolysis of metabolically labile amide bonds presents a safety risk through several mechanisms, including geno-, hepato- and nephrotoxicity. Whilst multiple in vitro systems used for studying metabolic stability dis...

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Detalles Bibliográficos
Autores principales: Bradshaw, Peter R., Wilson, Ian D., Gill, Rachel Upcott, Butler, Philip J., Dilworth, Clive, Athersuch, Toby J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799297/
https://www.ncbi.nlm.nih.gov/pubmed/29402925
http://dx.doi.org/10.1038/s41598-018-20464-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799297/
https://www.ncbi.nlm.nih.gov/pubmed/29402925
http://dx.doi.org/10.1038/s41598-018-20464-4

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