Cargando…

Neuroprotective effects of pifithrin-α against traumatic brain injury in the striatum through suppression of neuroinflammation, oxidative stress, autophagy, and apoptosis

Cortical and hippocampal neuronal damages caused by traumatic brain injury (TBI) are associated with motor and cognitive impairments; however, only little attention paid to the striatal damage. It is known that the p53 tumor-suppressor transcription factor participated in TBI-induced secondary brain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Ya-Ni, Yang, Ling-Yu, Greig, Nigel H., Wang, Yu-Chio, Lai, Chien-Cheng, Wang, Jia-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799311/ https://www.ncbi.nlm.nih.gov/pubmed/29402897 http://dx.doi.org/10.1038/s41598-018-19654-x

Ejemplares similares

Sequential combined Treatment of Pifithrin-α and Posiphen Enhances Neurogenesis and Functional Recovery After Stroke
por: Turcato, Flavia, et al.
Publicado: (2018)

0356. Effect of the neuroprotective p53-inhibitor pifithrin-µ in a rodent cardiac arrest model
por: Springe, D, et al.
Publicado: (2014)

Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells
por: McKeon, Aoife M., et al.
Publicado: (2016)

Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat
por: Wang, Jin-Ya, et al.
Publicado: (2016)

Antileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia
por: Kaiser, M, et al.
Publicado: (2011)

Lack of Autophagy Induction by Lithium Decreases Neuroprotective Effects in the Striatum of Aged Rats
por: Costa, Angelica Jardim, et al.
Publicado: (2021)

Erratum to: Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat
por: Wang, Jing-Ya, et al.
Publicado: (2016)

Rosiglitazone exerts neuroprotective effects via the suppression of neuronal autophagy and apoptosis in the cortex following traumatic brain injury
por: YAO, JUNCHAO, et al.
Publicado: (2015)

Regenerative repair of Pifithrin-α in cerebral ischemia via VEGF dependent manner
por: Zhang, Ping, et al.
Publicado: (2016)

The Anti-Inflammatory Effects of the Small Molecule Pifithrin-µ on BV2 Microglia
por: Fleiss, Bobbi, et al.
Publicado: (2015)

The neuroprotective effects of AMN082 on neuronal apoptosis in rats after traumatic brain injury
por: Lu, Chung-Che, et al.
Publicado: (2021)

Early electroacupuncture treatment ameliorates neuroinflammation in rats with traumatic brain injury
por: Tang, Wei-Chen, et al.
Publicado: (2016)

The p53-inhibitor Pifithrin-α inhibits Firefly Luciferase activity in vivo and in vitro
por: Rocha, Sonia, et al.
Publicado: (2003)

Pro-apoptotic Effect of Pifithrin-α on Preimplantation Porcine In vitro Fertilized Embryo Development
por: Mulligan, Brendan, et al.
Publicado: (2012)

Hydrogen Sulfide Offers Neuroprotection on Traumatic Brain Injury in Parallel with Reduced Apoptosis and Autophagy in Mice
por: Zhang, Mingyang, et al.
Publicado: (2014)

METH-Induced Neurotoxicity Is Alleviated by Lactulose Pretreatment Through Suppressing Oxidative Stress and Neuroinflammation in Rat Striatum
por: Xie, Xiao-Li, et al.
Publicado: (2018)

Methylprednisolone exerts neuroprotective effects by regulating autophagy and apoptosis
por: Gao, Wei, et al.
Publicado: (2016)

Pifithrin-α ameliorates glycerol induced rhabdomyolysis and acute kidney injury by reducing p53 activation
por: Yuqiang, Chen, et al.
Publicado: (2022)

AVE 0991 Suppresses Astrocyte-Mediated Neuroinflammation of Alzheimer’s Disease by Enhancing Autophagy
por: Deng, Yang, et al.
Publicado: (2023)

Targeting microthrombosis and neuroinflammation with vepoloxamer for therapeutic neuroprotection after traumatic brain injury
por: Xiong, Ye, et al.
Publicado: (2018)

Post-Injury Neuroprotective Effects of the Thalidomide Analog 3,6′-Dithiothalidomide on Traumatic Brain Injury
por: Batsaikhan, Buyandelger, et al.
Publicado: (2019)

bFGF plays a neuroprotective role by suppressing excessive autophagy and apoptosis after transient global cerebral ischemia in rats
por: Sun, Dawei, et al.
Publicado: (2018)

Correction: Griffith, D.M., et al. Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells. Molecules 2016, 21, 949
por: McKeon, Aoife M., et al.
Publicado: (2016)

Neuroinflammation: The Role of Anthocyanins as Neuroprotectants
por: Banji, Otilia J.F., et al.
Publicado: (2022)

Modafinil Abrogates Methamphetamine-Induced Neuroinflammation and Apoptotic Effects in the Mouse Striatum
por: Raineri, Mariana, et al.
Publicado: (2012)

(-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and Behavioral Impairments Induced by Traumatic Brain Injury in Mice
por: Hsueh, Shih-Chang, et al.
Publicado: (2019)

The neuroprotective effects of Lutongkeli in traumatic brain injury rats by anti-apoptosis mechanism
por: Xiao, Qiu-Xia, et al.
Publicado: (2022)

Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy
por: Rong, Yuluo, et al.
Publicado: (2019)

Association of exercise-induced autophagy upregulation and apoptosis suppression with neuroprotection against pharmacologically induced Parkinson's disease
por: Jang, Yong chul, et al.
Publicado: (2018)

Antiproliferative Activity of Cinnamomum cassia Constituents and Effects of Pifithrin-Alpha on Their Apoptotic Signaling Pathways in Hep G2 Cells
por: Ng, Lean-Teik, et al.
Publicado: (2011)

Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes
por: Zhu, Jiawei, et al.
Publicado: (2020)

Neuroinflammation, AD, and Dementia
por: Reale, Marcella, et al.
Publicado: (2010)

Role of Natural Antioxidants on Neuroprotection and Neuroinflammation
por: Nuzzo, Domenico
Publicado: (2021)

Childhood obesity is linked to putative neuroinflammation in brain white matter, hypothalamus, and striatum
por: Li, Zhaolong Adrian, et al.
Publicado: (2023)

Sirtuin 1 alleviates neuroinflammation‐induced apoptosis after traumatic brain injury
por: Wei, Guan, et al.
Publicado: (2021)

Cordycepin confers long-term neuroprotection via inhibiting neutrophil infiltration and neuroinflammation after traumatic brain injury
por: Wei, Pengju, et al.
Publicado: (2021)

Glucose-Dependent Insulinotropic Polypeptide Ameliorates Mild Traumatic Brain Injury-Induced Cognitive and Sensorimotor Deficits and Neuroinflammation in Rats
por: Yu, Yu-Wen, et al.
Publicado: (2016)

Modulation of autophagy for neuroprotection and functional recovery in traumatic spinal cord injury
por: Ray, Swapan K.
Publicado: (2020)

Agomir-331 Suppresses Reactive Gliosis and Neuroinflammation after Traumatic Brain Injury
por: Wang, Jin-Xing, et al.
Publicado: (2023)

Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus Renders Neuroprotection through the Suppression of Hippocampal Apoptosis: An Experimental Animal Study
por: Praveen Rajneesh, Chellappan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_73426mdudgk24g1jq0feedkrgh