Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC

The aberrant activation of Wnt signal transduction initiates the development of 90% of colorectal cancers, the majority of which arise from inactivation of the tumor suppressor Adenomatous polyposis coli (APC). In the classical model for Wnt signaling, the primary role of APC is to act, together wit...

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Detalles Bibliográficos
Autores principales: Tacchelly-Benites, Ofelia, Wang, Zhenghan, Yang, Eungi, Benchabane, Hassina, Tian, Ai, Randall, Michael P., Ahmed, Yashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800574/
https://www.ncbi.nlm.nih.gov/pubmed/29408853
http://dx.doi.org/10.1371/journal.pgen.1007178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800574/
https://www.ncbi.nlm.nih.gov/pubmed/29408853
http://dx.doi.org/10.1371/journal.pgen.1007178

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