Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations

HIV-1 envelope glycoprotein (Env) mediates virus attachment and entry into the host cells. Like other membrane-bound and secreted proteins, HIV-1 Env contains at its N terminus a signal peptide (SP) that directs the nascent Env to the endoplasmic reticulum (ER) where Env synthesis and post-translati...

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Detalles Bibliográficos
Autores principales: Upadhyay, Chitra, Feyznezhad, Roya, Yang, Weiming, Zhang, Hui, Zolla-Pazner, Susan, Hioe, Catarina E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800646/
https://www.ncbi.nlm.nih.gov/pubmed/29370305
http://dx.doi.org/10.1371/journal.ppat.1006812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800646/
https://www.ncbi.nlm.nih.gov/pubmed/29370305
http://dx.doi.org/10.1371/journal.ppat.1006812

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