STAT3 expression by myeloid cells is detrimental for the T- cell-mediated control of infection with Mycobacterium tuberculosis

STAT3 is a master regulator of the immune responses. Here we show that M. tuberculosis-infected stat3(fl/fl) lysm cre mice, defective for STAT3 in myeloid cells, contained lower bacterial load in lungs and spleens, reduced granuloma extension but higher levels of pulmonary neutrophils. STAT3-deficie...

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Detalles Bibliográficos
Autores principales: Gao, Yu, Basile, Juan Ignacio, Classon, Cajsa, Gavier-Widen, Dolores, Yoshimura, Akihiko, Carow, Berit, Rottenberg, Martin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800682/
https://www.ncbi.nlm.nih.gov/pubmed/29338039
http://dx.doi.org/10.1371/journal.ppat.1006809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800682/
https://www.ncbi.nlm.nih.gov/pubmed/29338039
http://dx.doi.org/10.1371/journal.ppat.1006809

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