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STAT3 expression by myeloid cells is detrimental for the T- cell-mediated control of infection with Mycobacterium tuberculosis
STAT3 is a master regulator of the immune responses. Here we show that M. tuberculosis-infected stat3(fl/fl) lysm cre mice, defective for STAT3 in myeloid cells, contained lower bacterial load in lungs and spleens, reduced granuloma extension but higher levels of pulmonary neutrophils. STAT3-deficie...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800682/ https://www.ncbi.nlm.nih.gov/pubmed/29338039 http://dx.doi.org/10.1371/journal.ppat.1006809 |