Inducible transgenic expression of tripeptidyl peptidase 1 in a mouse model of late-infantile neuronal ceroid lipofuscinosis

Late-infantile neuronal ceroid lipofuscinosis is a fatal neurodegenerative disease of children caused by mutations resulting in loss of activity of the lysosomal protease, tripeptidyl peptidase 1 (TPP1). While Tpp1-targeted mouse models of LINCL exist, the goal of this study was to create a transgen...

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Detalles Bibliográficos
Autores principales: Nemtsova, Yuliya, Wiseman, Jennifer A., El-Banna, Mukarram, Lobel, Peter, Sleat, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800698/
https://www.ncbi.nlm.nih.gov/pubmed/29408933
http://dx.doi.org/10.1371/journal.pone.0192286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800698/
https://www.ncbi.nlm.nih.gov/pubmed/29408933
http://dx.doi.org/10.1371/journal.pone.0192286

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