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p37/UBXN2B regulates spindle orientation by limiting cortical NuMA recruitment via PP1/Repo-Man
Spindle orientation determines the axis of division and is crucial for cell fate, tissue morphogenesis, and the development of an organism. In animal cells, spindle orientation is regulated by the conserved Gαi–LGN–NuMA complex, which targets the force generator dynein–dynactin to the cortex. In thi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800812/ https://www.ncbi.nlm.nih.gov/pubmed/29222185 http://dx.doi.org/10.1083/jcb.201707050 |