Non-Hematopoietic MLKL Protects Against Salmonella Mucosal Infection by Enhancing Inflammasome Activation

The intestinal mucosal barrier is critical for host defense against pathogens infection. Here, we demonstrate that the mixed lineage kinase-like protein (MLKL), a necroptosis effector, promotes intestinal epithelial barrier function by enhancing inflammasome activation. MLKL(−/−) mice were more susc...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Shui-Xing, Chen, Wei, Liu, Zhen-Zhen, Zhou, Feng-Hua, Yan, Shi-Qing, Hu, Gui-Qiu, Qin, Xiao-Xia, Zhang, Jie, Ma, Ke, Du, Chong-Tao, Gu, Jing-Min, Deng, Xu-Ming, Han, Wen-Yu, Yang, Yong-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801401/
https://www.ncbi.nlm.nih.gov/pubmed/29456533
http://dx.doi.org/10.3389/fimmu.2018.00119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801401/
https://www.ncbi.nlm.nih.gov/pubmed/29456533
http://dx.doi.org/10.3389/fimmu.2018.00119

Ejemplares similares