CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection

Herpes simplex virus 1 (HSV-1) establishes latent infection in neurons via a variety of epigenetic mechanisms that silence its genome. The cellular CCCTC-binding factor (CTCF) functions as a mediator of transcriptional control and chromatin organization and has binding sites in the HSV-1 genome. We...

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Detalles Bibliográficos
Autores principales: Lee, Jennifer S., Raja, Priya, Pan, Dongli, Pesola, Jean M., Coen, Donald M., Knipe, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801469/
https://www.ncbi.nlm.nih.gov/pubmed/29437926
http://dx.doi.org/10.1128/mBio.02372-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801469/
https://www.ncbi.nlm.nih.gov/pubmed/29437926
http://dx.doi.org/10.1128/mBio.02372-17

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