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CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection
Herpes simplex virus 1 (HSV-1) establishes latent infection in neurons via a variety of epigenetic mechanisms that silence its genome. The cellular CCCTC-binding factor (CTCF) functions as a mediator of transcriptional control and chromatin organization and has binding sites in the HSV-1 genome. We...
Autores principales: | Lee, Jennifer S., Raja, Priya, Pan, Dongli, Pesola, Jean M., Coen, Donald M., Knipe, David M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801469/ https://www.ncbi.nlm.nih.gov/pubmed/29437926 http://dx.doi.org/10.1128/mBio.02372-17 |
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