The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K(+) stimulation but not cortical spreading depression-induced afferent sensitization

INTRODUCTION: Cortical spreading depression (CSD) is believed to promote migraine headache by enhancing the activity and mechanosensitivity of trigeminal intracranial meningeal afferents. One putative mechanism underlying this afferent response involves an acute excitation of meningeal afferents by...

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Detalles Bibliográficos
Autores principales: Zhao, Jun, Levy, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2017
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802320/
https://www.ncbi.nlm.nih.gov/pubmed/29430561
http://dx.doi.org/10.1097/PR9.0000000000000632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802320/
https://www.ncbi.nlm.nih.gov/pubmed/29430561
http://dx.doi.org/10.1097/PR9.0000000000000632

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