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Soluble Tau has devastating effects on the structural plasticity of hippocampal granule neurons

Tau is a neuronal microtubule-associated protein with countless physiological functions. Although the detrimental effects of insoluble aggregated Tau have been widely studied, recent evidence supports the notion that soluble Tau (composed mostly of monomers and dimers) is also toxic for neurons. Her...

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Detalles Bibliográficos
Autores principales: Bolós, M, Pallas-Bazarra, N, Terreros-Roncal, J, Perea, JR, Jurado-Arjona, J, Ávila, J, Llorens-Martín, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802513/
https://www.ncbi.nlm.nih.gov/pubmed/29217824
http://dx.doi.org/10.1038/s41398-017-0013-6