Cargando…

Involvement of PKA/DARPP-32/PP1α and β- arrestin/Akt/GSK-3β Signaling in Cadmium-Induced DA-D2 Receptor-Mediated Motor Dysfunctions: Protective Role of Quercetin

Given increasing risk of cadmium-induced neurotoxicity, the study was conducted to delineate the molecular mechanisms associated with cadmium-induced motor dysfunctions and identify targets that govern dopaminergic signaling in the brain involving in vivo, in vitro, and in silico approaches. Selecti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gupta, Richa, Shukla, Rajendra K., Pandey, Ankita, Sharma, Tanuj, Dhuriya, Yogesh K., Srivastava, Pranay, Singh, Manjul P., Siddiqi, Mohammad Imran, Pant, Aditya B., Khanna, Vinay K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802731/ https://www.ncbi.nlm.nih.gov/pubmed/29410441 http://dx.doi.org/10.1038/s41598-018-20342-z

Ejemplares similares

Transient Calcium and Dopamine Increase PKA Activity and DARPP-32 Phosphorylation
por: Lindskog, Maria, et al.
Publicado: (2006)

Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells
por: Vangamudi, Bhavatarini, et al.
Publicado: (2011)

Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases
por: Singh, Shripriya, et al.
Publicado: (2016)

Phosphorylation of human CEACAM1-LF by PKA and GSK3β promotes its interaction with β-catenin
por: Hu, Weidong, et al.
Publicado: (2021)

β-Arrestin1 Promotes Colorectal Cancer Metastasis Through GSK-3β/β-Catenin Signaling- Mediated Epithelial-to-Mesenchymal Transition
por: Song, Qing, et al.
Publicado: (2021)

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1
por: Rodriguiz, Ramona M., et al.
Publicado: (2021)

PP1, PKA and DARPP‐32 in breast cancer: A retrospective assessment of protein and mRNA expression
por: Saidy, Behnaz, et al.
Publicado: (2021)

Imperatorin Positively Regulates Melanogenesis through Signaling Pathways Involving PKA/CREB, ERK, AKT, and GSK3β/β-Catenin
por: Kim, Taejin, et al.
Publicado: (2022)

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist
por: Erickson, Catherine E., et al.
Publicado: (2013)

Darpp-32 and t-Darpp are differentially expressed in normal and malignant mouse mammary tissue
por: Christenson, Jessica L, et al.
Publicado: (2014)

Catalytic activation of β-arrestin by GPCRs
por: Eichel, Kelsie, et al.
Publicado: (2018)

β-arrestin2/miR-155/GSK3β regulates transition of 5′-azacytizine-induced Sca-1-positive cells to cardiomyocytes
por: Zhao, Jing, et al.
Publicado: (2014)

ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins
por: Matti, Christoph, et al.
Publicado: (2020)

Motor Skill Learning Is Associated with Phase-Dependent Modifications in the Striatal cAMP/PKA/DARPP-32 Signaling Pathway in Rodents
por: Qian, Yu, et al.
Publicado: (2015)

CTIP2-Regulated Reduction in PKA-Dependent DARPP32 Phosphorylation in Human Medium Spiny Neurons: Implications for Huntington Disease
por: Fjodorova, Marija, et al.
Publicado: (2019)

Quercetin Suppresses Human Glioblastoma Migration and Invasion via GSK3β/β-catenin/ZEB1 Signaling Pathway
por: Chen, Bo, et al.
Publicado: (2022)

Targeting ER stress/PKA/GSK-3β/β-catenin pathway as a potential novel strategy for hepatitis C virus-infected patients
por: Lin, Dong, et al.
Publicado: (2023)

6-Methylcoumarin Promotes Melanogenesis through the PKA/CREB, MAPK, AKT/PI3K, and GSK3β/β-Catenin Signaling Pathways
por: Kim, Taejin, et al.
Publicado: (2023)

Necroptosis: a regulated inflammatory mode of cell death
por: Dhuriya, Yogesh K., et al.
Publicado: (2018)

Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β-arrestins in the heart
por: Lymperopoulos, Anastasios, et al.
Publicado: (2019)

Multifaceted role of β-arrestins in inflammation and disease
por: Sharma, Deepika, et al.
Publicado: (2015)

β-Arrestin-Dependent Deactivation of Mouse Melanopsin
por: Cameron, Evan G., et al.
Publicado: (2014)

Phosphorylation of β-arrestin2 at Thr(383) by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs
por: Cassier, Elisabeth, et al.
Publicado: (2017)

β-Arrestin1 and β-Arrestin2 Are Required to Support the Activity of the CXCL12/HMGB1 Heterocomplex on CXCR4
por: D’Agostino, Gianluca, et al.
Publicado: (2020)

Structure of the Neurotensin Receptor 1 in complex with β-arrestin 1
por: Huang, Weijiao, et al.
Publicado: (2020)

PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice
por: Zhang, Jingliang, et al.
Publicado: (2021)

Haloperidol-Induced Immediate Early Genes in Striatopallidal Neurons Requires the Converging Action of cAMP/PKA/DARPP-32 and mTOR Pathways
por: Onimus, Oriane, et al.
Publicado: (2022)

Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics
por: Janetzko, John, et al.
Publicado: (2022)

DARPP-32: from neurotransmission to cancer
por: Belkhiri, Abbes, et al.
Publicado: (2016)

The involvement of DARPP-32 in the pathophysiology of schizophrenia
por: Wang, Haitao, et al.
Publicado: (2017)

DARPP-32 and t-DARPP promote non-small cell lung cancer growth through regulation of IKKα-dependent cell migration
por: Alam, Sk. Kayum, et al.
Publicado: (2018)

β-Arrestin2 arrests the clearance of tau in FTLD
por: Thathiah, Amantha
Publicado: (2020)

Functional competence of a partially engaged GPCR–β-arrestin complex
por: Kumari, Punita, et al.
Publicado: (2016)

Distinct and Shared Roles of β-Arrestin-1 and β-Arrestin-2 on the Regulation of C3a Receptor Signaling in Human Mast Cells
por: Vibhuti, Arpana, et al.
Publicado: (2011)

The single nucleotide β -arrestin2 variant, A248T, resembles dynamical properties of activated arrestin
por: ŞENSOY, Özge
Publicado: (2020)

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs
por: McCorvy, John D., et al.
Publicado: (2017)

Miglitol, an Oral Antidiabetic Drug, Downregulates Melanogenesis in B16F10 Melanoma Cells through the PKA, MAPK, and GSK3β/β-Catenin Signaling Pathways
por: Kim, Hyeon-Mi, et al.
Publicado: (2022)

Darpp-32 and Its Truncated Variant t-Darpp Have Antagonistic Effects on Breast Cancer Cell Growth and Herceptin Resistance
por: Gu, Long, et al.
Publicado: (2009)

DARPP-32 and t-DARPP in the development of resistance to anti-HER2 agents. Pre-clinical evidence from the STEP study
por: Bon, Giulia, et al.
Publicado: (2023)

β-arrestin-1 and β-arrestin-2 Restrain MRGPRX2-Triggered Degranulation and ERK1/2 Activation in Human Skin Mast Cells
por: Wang, Zhao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8shu1ucpaqh8n8nisn88q8k4k6