OPA1 gene therapy prevents retinal ganglion cell loss in a Dominant Optic Atrophy mouse model

Dominant optic atrophy (DOA) is a rare progressive and irreversible blinding disease which is one of the most frequent forms of hereditary optic neuropathy. DOA is mainly caused by dominant mutation in the OPA1 gene encoding a large mitochondrial GTPase with crucial roles in membrane dynamics and ce...

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Detalles Bibliográficos
Autores principales: Sarzi, Emmanuelle, Seveno, Marie, Piro-Mégy, Camille, Elzière, Lucie, Quilès, Mélanie, Péquignot, Marie, Müller, Agnès, Hamel, Christian P., Lenaers, Guy, Delettre, Cécile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802757/
https://www.ncbi.nlm.nih.gov/pubmed/29410463
http://dx.doi.org/10.1038/s41598-018-20838-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802757/
https://www.ncbi.nlm.nih.gov/pubmed/29410463
http://dx.doi.org/10.1038/s41598-018-20838-8

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