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Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-β-synthase

Cystathionine-β-synthase (CBS) belongs to a large family of pyridoxal 5’-phosphate (PLP)-dependent enzymes, responsible for the sulfur metabolism. The heme-dependent protein CBS is part of regulatory pathways also involving the gasotransmitter hydrogen sulfide. Malfunction of CBS can lead to patholo...

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Detalles Bibliográficos
Autores principales: Kumar, Amit, Wißbrock, Amelie, Goradia, Nishit, Bellstedt, Peter, Ramachandran, Ramadurai, Imhof, Diana, Ohlenschläger, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802807/
https://www.ncbi.nlm.nih.gov/pubmed/29410458
http://dx.doi.org/10.1038/s41598-018-20841-z