Cargando…

Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-β-synthase

Cystathionine-β-synthase (CBS) belongs to a large family of pyridoxal 5’-phosphate (PLP)-dependent enzymes, responsible for the sulfur metabolism. The heme-dependent protein CBS is part of regulatory pathways also involving the gasotransmitter hydrogen sulfide. Malfunction of CBS can lead to patholo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Amit, Wißbrock, Amelie, Goradia, Nishit, Bellstedt, Peter, Ramachandran, Ramadurai, Imhof, Diana, Ohlenschläger, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802807/ https://www.ncbi.nlm.nih.gov/pubmed/29410458 http://dx.doi.org/10.1038/s41598-018-20841-z

Ejemplares similares

Structural insights into heme binding to IL-36α proinflammatory cytokine
por: Wißbrock, Amelie, et al.
Publicado: (2019)

Heme-Thiolate Perturbation in Cystathionine β-Synthase by Mercury Compounds
por: Benchoam, Dayana, et al.
Publicado: (2021)

The molecular basis of transient heme-protein interactions: analysis, concept and implementation
por: Wißbrock, Amelie, et al.
Publicado: (2019)

HeMoQuest: a webserver for qualitative prediction of transient heme binding to protein motifs
por: Paul George, Ajay Abisheck, et al.
Publicado: (2020)

Cystathionine β-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter
por: Zhao, Peng, et al.
Publicado: (2019)

Cystathionine β-Synthase in Physiology and Cancer
por: Zhu, Haoran, et al.
Publicado: (2018)

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)
por: Asimakopoulou, Antonia, et al.
Publicado: (2013)

Vascular presentation of cystathionine beta-synthase deficiency in adulthood
por: Magner, Martin, et al.
Publicado: (2010)

Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
por: Morris, Andrew A. M., et al.
Publicado: (2016)

Cystathionine β-Synthase Is Necessary for Axis Development in Vivo
por: Prabhudesai, Shubhangi, et al.
Publicado: (2018)

Association of Cystathionine β-Synthase Gene Polymorphisms With Preeclampsia
por: de León Bautista, Mercedes Piedad, et al.
Publicado: (2018)

Cystathionine-β-synthase: Molecular Regulation and Pharmacological Inhibition
por: Zuhra, Karim, et al.
Publicado: (2020)

Structural Insights into a Wildtype Domain of the Oncoprotein E6 and Its Interaction with a PDZ Domain
por: Mischo, André, et al.
Publicado: (2013)

Expression of Cystathionine β-synthase and Cystathionine γ-lyase in Human Pregnant Myometrium and Their Roles in the Control of Uterine Contractility
por: You, Xing-Ji, et al.
Publicado: (2011)

Enhanced Expression of Cystathionine β-Synthase and Cystathionine γ-Lyase During Acute Cholecystitis-Induced Gallbladder Inflammation
por: Zhang, Li, et al.
Publicado: (2013)

Downregulation of cystathionine β‐synthase and cystathionine γ‐lyase expression stimulates inflammation in kidney ischemia–reperfusion injury
por: Wang, Pengqi, et al.
Publicado: (2014)

Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase
por: Ahmad, Akbar, et al.
Publicado: (2016)

Chemical chaperone rescue of mutant human cystathionine β-synthase
por: Singh, Laishram R., et al.
Publicado: (2007)

Cystathionine Beta-Synthase Deficiency Causes Fat Loss in Mice
por: Gupta, Sapna, et al.
Publicado: (2011)

Brain Phenotype of Transgenic Mice Overexpressing Cystathionine β-Synthase
por: Régnier, Vinciane, et al.
Publicado: (2012)

Domain Organization, Catalysis and Regulation of Eukaryotic Cystathionine Beta-Synthases
por: Majtan, Tomas, et al.
Publicado: (2014)

Cystathionine beta synthase modulates senescence of human endothelial cells
por: Albertini, Eva, et al.
Publicado: (2012)

Role of cystathionine beta synthase in lipid metabolism in ovarian cancer
por: Chakraborty, Prabir K., et al.
Publicado: (2015)

Corrigendum: Cystathionine β-Synthase Is Necessary for Axis Development in vivo
por: Prabhudesai, Shubhangi, et al.
Publicado: (2018)

Emerging roles of cystathionine β-synthase in various forms of cancer
por: Ascenção, Kelly, et al.
Publicado: (2022)

H(2)S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes
por: Nandi, Shyam Sundar, et al.
Publicado: (2017)

Down-Regulated Expression of Cystathionine β-Synthase and Cystathionine γ-Lyase in Varicocele, and Infertile Men: A Case-Control Study
por: Akbarian, Fahimeh, et al.
Publicado: (2022)

Structure of the cystathionine γ-synthase MetB from Mycobacterium ulcerans
por: Clifton, Matthew C., et al.
Publicado: (2011)

Cystathionine β-Synthase Mutations: Effect of Mutation Topology on Folding and Activity
por: Kožich, Viktor, et al.
Publicado: (2010)

Specific downregulation of cystathionine β‐synthase expression in the kidney during obesity
por: Liu, Mi, et al.
Publicado: (2018)

Cystathionine β-synthase and methylenetetrahydrofolate reductase mutations in Mexican individuals with hyperhomocysteinemia
por: Figueroa-Torres, Anahi Guadalupe, et al.
Publicado: (2020)

A proactive genotype-to-patient-phenotype map for cystathionine beta-synthase
por: Sun, Song, et al.
Publicado: (2020)

S-Adenosylmethionine–responsive cystathionine β-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis
por: Bandyopadhyay, Parijat, et al.
Publicado: (2022)

3-Mercaptopyruvate Sulfurtransferase, Not Cystathionine β-Synthase Nor Cystathionine γ-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells
por: Tao, Beibei, et al.
Publicado: (2017)

Linking Labile Heme with Thrombosis
por: Hopp, Marie-Thérèse, et al.
Publicado: (2021)

Sequential acquisition of multi-dimensional heteronuclear chemical shift correlation spectra with (1)H detection
por: Bellstedt, Peter, et al.
Publicado: (2014)

Solution structure of stem-loop α of the hepatitis B virus post-transcriptional regulatory element
por: Schwalbe, Martin, et al.
Publicado: (2008)

Restoring assembly and activity of cystathionine β-synthase mutants by ligands and chemical chaperones
por: Kopecká, Jana, et al.
Publicado: (2010)

Cystathionine β-Synthase p.S466L Mutation Causes Hyperhomocysteinemia in Mice
por: Gupta, Sapna, et al.
Publicado: (2008)

Severe Crohn’s Disease Manifestations in a Child with Cystathionine β-Synthase Deficiency
por: Alsahli, Saud, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_itdi5gfhh607hj5drta3fic390