Quinacrine upregulates p21/p27 independent of p53 through autophagy-mediated downregulation of p62-Skp2 axis in ovarian cancer

We have previously shown that the anti-malarial compound Quinacrine (QC) inhibits ovarian cancer (OC) growth by modulating autophagy. In the present study we extended these studies to identify the molecular pathways regulated by QC to promote apoptosis independent of p53 status in OC. QC exhibited s...

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Detalles Bibliográficos
Autores principales: Jung, DeokBeom, Khurana, Ashwani, Roy, Debarshi, Kalogera, Eleftheria, Bakkum-Gamez, Jamie, Chien, Jeremy, Shridhar, Viji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802832/
https://www.ncbi.nlm.nih.gov/pubmed/29410485
http://dx.doi.org/10.1038/s41598-018-20531-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802832/
https://www.ncbi.nlm.nih.gov/pubmed/29410485
http://dx.doi.org/10.1038/s41598-018-20531-w

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