Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells in pancreatic islets are progressively destroyed. Clinical trials of immunotherapies in recently diagnosed T1D patients have only transiently and partially impacted the disease course, suggesting that other approach...

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Detalles Bibliográficos
Autores principales: Simeonovic, Charmaine J., Popp, Sarah K., Starrs, Lora M., Brown, Debra J., Ziolkowski, Andrew F., Ludwig, Barbara, Bornstein, Stefan R., Wilson, J. Dennis, Pugliese, Alberto, Kay, Thomas W. H., Thomas, Helen E., Loudovaris, Thomas, Choong, Fui Jiun, Freeman, Craig, Parish, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802856/
https://www.ncbi.nlm.nih.gov/pubmed/29415062
http://dx.doi.org/10.1371/journal.pone.0191360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802856/
https://www.ncbi.nlm.nih.gov/pubmed/29415062
http://dx.doi.org/10.1371/journal.pone.0191360

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