BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage

BRCA2 is essential for maintaining genomic integrity. BRCA2-deficient primary cells are either not viable or exhibit severe proliferation defects. Yet, BRCA2 deficiency contributes to tumorigenesis. It is believed that mutations in genes such as TRP53 allow BRCA2 heterozygous cells to overcome growt...

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Detalles Bibliográficos
Autores principales: Biswas, Kajal, Philip, Subha, Yadav, Aditya, Martin, Betty K., Burkett, Sandra, Singh, Vaibhav, Babbar, Anav, North, Susan Lynn, Chang, Suhwan, Sharan, Shyam K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803202/
https://www.ncbi.nlm.nih.gov/pubmed/29416040
http://dx.doi.org/10.1038/s41467-018-03020-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803202/
https://www.ncbi.nlm.nih.gov/pubmed/29416040
http://dx.doi.org/10.1038/s41467-018-03020-6

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