Molecular dynamic simulations reveal structural insights into substrate and inhibitor binding modes and functionality of Ecto-Nucleoside Triphosphate Diphosphohydrolases

Ecto-nucleotidase enzymes catalyze the hydrolysis of extracellular nucleotides to their respective nucleosides. Herein, we place the focus on the elucidation of structural features of the cell surface located ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDase1-3 and 8). The physiological ro...

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Detalles Bibliográficos
Autores principales: Iqbal, Jamshed, Shah, Syed Jawad Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803232/
https://www.ncbi.nlm.nih.gov/pubmed/29416085
http://dx.doi.org/10.1038/s41598-018-20971-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803232/
https://www.ncbi.nlm.nih.gov/pubmed/29416085
http://dx.doi.org/10.1038/s41598-018-20971-4

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