Pharmacological Blockade of ASCT2-dependent Glutamine Transport Leads To Anti-tumor Efficacy in Preclinical Models

The unique metabolic demands of cancer cells underscore potentially fruitful opportunities for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer metabolism has led to surprisingly few new drugs to date. The neutral amino acid glutamine serves as a key intermed...

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Detalles Bibliográficos
Autores principales: Schulte, Michael L., Fu, Allie, Zhao, Ping, Li, Jun, Geng, Ling, Smith, Shannon T., Kondo, Jumpei, Coffey, Robert J., Johnson, Marc O., Rathmell, Jeffrey C., Sharick, Joe T., Skala, Melissa C., Smith, Jarrod A., Berlin, Jordan, Washington, M. Kay, Nickels, Michael L., Manning, H. Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803339/
https://www.ncbi.nlm.nih.gov/pubmed/29334372
http://dx.doi.org/10.1038/nm.4464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803339/
https://www.ncbi.nlm.nih.gov/pubmed/29334372
http://dx.doi.org/10.1038/nm.4464

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