Positively selected enhancer elements endow osteosarcoma cells with metastatic competence

Metastasis results from a complex set of traits acquired by tumor cells, distinct from those necessary for tumorigenesis. Here, we investigate the contribution of enhancer elements to the metastatic phenotype of osteosarcoma. Through epigenomic profiling, we identify substantial differences in enhan...

Descripción completa

Detalles Bibliográficos
Autores principales: Morrow, James J., Bayles, Ian, Funnell, Alister PW, Miller, Tyler E., Saiakhova, Alina, Lizardo, Michael M., Bartels, Cynthia F., Kapteijn, Maaike Y., Hung, Stevephen, Mendoza, Arnulfo, Dhillon, Gursimran, Chee, Daniel R., Myers, Jay T., Allen, Frederick, Gambarotti, Marco, Righi, Alberto, DiFeo, Analisa, Rubin, Brian P., Huang, Alex Y., Meltzer, Paul S., Helman, Lee J., Picci, Piero, Versteeg, Henri, Stamatoyannopolus, John, Khanna, Chand, Scacheri, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803371/
https://www.ncbi.nlm.nih.gov/pubmed/29334376
http://dx.doi.org/10.1038/nm.4475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803371/
https://www.ncbi.nlm.nih.gov/pubmed/29334376
http://dx.doi.org/10.1038/nm.4475

Ejemplares similares