Positively selected enhancer elements endow osteosarcoma cells with metastatic competence

Metastasis results from a complex set of traits acquired by tumor cells, distinct from those necessary for tumorigenesis. Here, we investigate the contribution of enhancer elements to the metastatic phenotype of osteosarcoma. Through epigenomic profiling, we identify substantial differences in enhan...

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Detalles Bibliográficos
Autores principales: Morrow, James J., Bayles, Ian, Funnell, Alister PW, Miller, Tyler E., Saiakhova, Alina, Lizardo, Michael M., Bartels, Cynthia F., Kapteijn, Maaike Y., Hung, Stevephen, Mendoza, Arnulfo, Dhillon, Gursimran, Chee, Daniel R., Myers, Jay T., Allen, Frederick, Gambarotti, Marco, Righi, Alberto, DiFeo, Analisa, Rubin, Brian P., Huang, Alex Y., Meltzer, Paul S., Helman, Lee J., Picci, Piero, Versteeg, Henri, Stamatoyannopolus, John, Khanna, Chand, Scacheri, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803371/
https://www.ncbi.nlm.nih.gov/pubmed/29334376
http://dx.doi.org/10.1038/nm.4475

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