The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation

The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the ‘Warburg effect’. The activation and further metabolism of glucose is initiated by hexokinase, a focal point of metabolic regulation. The human hexokinase 2 (HK2)...

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Detalles Bibliográficos
Autores principales: Nawaz, Mir Hussain, Ferreira, Juliana C., Nedyalkova, Lyudmila, Zhu, Haizhong, Carrasco-López, César, Kirmizialtin, Serdal, Rabeh, Wael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803496/
https://www.ncbi.nlm.nih.gov/pubmed/29298880
http://dx.doi.org/10.1042/BSR20171666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803496/
https://www.ncbi.nlm.nih.gov/pubmed/29298880
http://dx.doi.org/10.1042/BSR20171666

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