Discovery and cellular stress pathway analysis of 1,4-naphthoquinone derivatives with novel, highly potent broad-spectrum anticancer activity

BACKGROUND: Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mechanism of action of novel small molecules that interfere with critical pathways...

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Detalles Bibliográficos
Autores principales: Ghosh, Sajal K., Ganta, Abhishek, Spanjaard, Remco A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804083/
https://www.ncbi.nlm.nih.gov/pubmed/29422060
http://dx.doi.org/10.1186/s12929-018-0408-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804083/
https://www.ncbi.nlm.nih.gov/pubmed/29422060
http://dx.doi.org/10.1186/s12929-018-0408-6

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