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Comparison of (68)Ga-DOTA-Siglec-9 and (18)F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry

Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1). We compared (68)Ga-DOTA- and (18)F-fluorodeoxyribose- (FDR-) labeled Siglec-9 motif peptides for PET imaging of inflammation. Methods. Firstly, we examined (68)Ga-DO...

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Detalles Bibliográficos
Autores principales: Virtanen, Helena, Silvola, Johanna M. U., Autio, Anu, Li, Xiang-Guo, Liljenbäck, Heidi, Hellberg, Sanna, Siitonen, Riikka, Ståhle, Mia, Käkelä, Meeri, Airaksinen, Anu J., Helariutta, Kerttuli, Tolvanen, Tuula, Veres, Tibor Z., Saraste, Antti, Knuuti, Juhani, Jalkanen, Sirpa, Roivainen, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804415/
https://www.ncbi.nlm.nih.gov/pubmed/29463960
http://dx.doi.org/10.1155/2017/7645070
Descripción
Sumario:Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1). We compared (68)Ga-DOTA- and (18)F-fluorodeoxyribose- (FDR-) labeled Siglec-9 motif peptides for PET imaging of inflammation. Methods. Firstly, we examined (68)Ga-DOTA-Siglec-9 and (18)F-FDR-Siglec-9 in rats with skin/muscle inflammation. We then studied (18)F-FDR-Siglec-9 for the detection of inflamed atherosclerotic plaques in mice and compared it with previous (68)Ga-DOTA-Siglec-9 results. Lastly, we estimated human radiation dosimetry from the rat data. Results. In rats, (68)Ga-DOTA-Siglec-9 (SUV, 0.88 ± 0.087) and (18)F-FDR-Siglec-9 (SUV, 0.77 ± 0.22) showed comparable (P = 0.29) imaging of inflammation. In atherosclerotic mice, (18)F-FDR-Siglec-9 detected inflamed plaques with a target-to-background ratio (1.6 ± 0.078) similar to previously tested (68)Ga-DOTA-Siglec-9 (P = 0.35). Human effective dose estimates for (68)Ga-DOTA-Siglec-9 and (18)F-FDR-Siglec-9 were 0.024 and 0.022 mSv/MBq, respectively. Conclusion. Both tracers are suitable for PET imaging of inflammation. The easier production and lower cost of (68)Ga-DOTA-Siglec-9 present advantages over (18)F-FDR-Siglec-9, indicating it as a primary choice for clinical studies.