One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues

Chemoenzymatic reaction cascades can provide access to chiral compounds from low-cost starting materials in one pot. Here we describe one-pot asymmetric routes to tetrahydroisoquinoline alkaloids (THIAs) using the Pictet–Spenglerase norcoclaurine synthase (NCS) followed by a cyclisation, to give alk...

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Detalles Bibliográficos
Autores principales: Zhao, Jianxiong, Lichman, Benjamin R., Ward, John M., Hailes, Helen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804477/
https://www.ncbi.nlm.nih.gov/pubmed/29345260
http://dx.doi.org/10.1039/c7cc08024g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804477/
https://www.ncbi.nlm.nih.gov/pubmed/29345260
http://dx.doi.org/10.1039/c7cc08024g

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