RNA interference-based functional knockdown of the voltage-gated potassium channel Kv7.2 in dorsal root ganglion neurons after in vitro and in vivo gene transfer by adeno-associated virus vectors

Activation of the neuronal potassium channel Kv7.2 encoded by the KCNQ2 gene has recently been shown to be an attractive mechanism to inhibit nociceptive transmission. However, potent, selective, and clinically proven activators of Kv7.2/Kv7.3 currents with analgesic properties are still lacking. An...

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Detalles Bibliográficos
Autores principales: Valdor, Markus, Wagner, Anke, Röhrs, Viola, Berg, Johanna, Fechner, Henry, Schröder, Wolfgang, Tzschentke, Thomas M, Bahrenberg, Gregor, Christoph, Thomas, Kurreck, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805000/
https://www.ncbi.nlm.nih.gov/pubmed/29212407
http://dx.doi.org/10.1177/1744806917749669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805000/
https://www.ncbi.nlm.nih.gov/pubmed/29212407
http://dx.doi.org/10.1177/1744806917749669

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