Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers

Fibroblast growth factor receptors (FGFRs) are promising targets for antibody-based cancer therapies, as their substantial overexpression has been found in various tumor cells. Aberrant activation of FGF receptor 2 (FGFR2) signaling through overexpression of FGFR2 and/or its ligands, mutations, or r...

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Detalles Bibliográficos
Autores principales: Borek, Aleksandra, Sokolowska-Wedzina, Aleksandra, Chodaczek, Grzegorz, Otlewski, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805272/
https://www.ncbi.nlm.nih.gov/pubmed/29420662
http://dx.doi.org/10.1371/journal.pone.0192194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805272/
https://www.ncbi.nlm.nih.gov/pubmed/29420662
http://dx.doi.org/10.1371/journal.pone.0192194

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