Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation

The catalytic activity of trypsin-like serine proteases is in many cases regulated by conformational changes initiated by binding of physiological modulators to exosites located distantly from the active site. A trypsin-like serine protease of particular interest is urokinase-type plasminogen activa...

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Detalles Bibliográficos
Autores principales: Kromann-Hansen, Tobias, Lange, Eva Louise, Lund, Ida K., Høyer-Hansen, Gunilla, Andreasen, Peter A., Komives, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805342/
https://www.ncbi.nlm.nih.gov/pubmed/29420634
http://dx.doi.org/10.1371/journal.pone.0192661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805342/
https://www.ncbi.nlm.nih.gov/pubmed/29420634
http://dx.doi.org/10.1371/journal.pone.0192661

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