mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma

Overexpression of Rictor has been demonstrated to result in increased mTORC2 nucleation and activity leading to tumor growth and increased invasive characteristics in glioblastoma multiforme (GBM). However the mechanisms regulating Rictor expression in these tumors is not clearly understood. In this...

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Detalles Bibliográficos
Autores principales: Holmes, Brent, Benavides-Serrato, Angelica, Freeman, Ryan S., Landon, Kenna A., Bashir, Tariq, Nishimura, Robert N., Gera, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805585/
https://www.ncbi.nlm.nih.gov/pubmed/29059166
http://dx.doi.org/10.1038/onc.2017.360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805585/
https://www.ncbi.nlm.nih.gov/pubmed/29059166
http://dx.doi.org/10.1038/onc.2017.360

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