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Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes
Epigenetic regulation is mediated by protein complexes that couple recognition of chromatin marks to activity or recruitment of chromatin-modifying enzymes. Polycomb repressive complex 2 (PRC2), a gene silencer that methylates lysine 27 of histone H3, is stimulated upon recognition of its own cataly...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805599/ https://www.ncbi.nlm.nih.gov/pubmed/29379173 http://dx.doi.org/10.1038/s41594-018-0023-y |