The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd

Mycobacterial energy metabolism currently attracts strong attention as new target space for development of anti-tuberculosis drugs. The imidazopyridine Q203 targets the cytochrome bcc complex of the respiratory chain, a key component in energy metabolism. Q203 blocks growth of Mycobacterium tubercul...

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Detalles Bibliográficos
Autores principales: Lu, Ping, Asseri, Amer H., Kremer, Martijn, Maaskant, Janneke, Ummels, Roy, Lill, Holger, Bald, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805707/
https://www.ncbi.nlm.nih.gov/pubmed/29422632
http://dx.doi.org/10.1038/s41598-018-20989-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805707/
https://www.ncbi.nlm.nih.gov/pubmed/29422632
http://dx.doi.org/10.1038/s41598-018-20989-8

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