In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density

This work uses Monte Carlo simulations to investigate the dependence of residual and misrepaired double strand breaks (DSBs) at 24 hours on the initial damage pattern created during ion therapy. We present results from a nanometric DNA damage simulation coupled to a mechanistic model of Non-Homologo...

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Detalles Bibliográficos
Autores principales: Henthorn, N. T., Warmenhoven, J. W., Sotiropoulos, M., Mackay, R. I., Kirkby, N. F., Kirkby, K. J., Merchant, M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805743/
https://www.ncbi.nlm.nih.gov/pubmed/29422642
http://dx.doi.org/10.1038/s41598-018-21111-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805743/
https://www.ncbi.nlm.nih.gov/pubmed/29422642
http://dx.doi.org/10.1038/s41598-018-21111-8

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