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Gating mechanism of Kv11.1 (hERG) K(+) channels without covalent connection between voltage sensor and pore domains
Kv11.1 (hERG, KCNH2) is a voltage-gated potassium channel crucial in setting the cardiac rhythm and the electrical behaviour of several non-cardiac cell types. Voltage-dependent gating of Kv11.1 can be reconstructed from non-covalently linked voltage sensing and pore modules (split channels), challe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805800/ https://www.ncbi.nlm.nih.gov/pubmed/29270671 http://dx.doi.org/10.1007/s00424-017-2093-9 |