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C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes

Increasing evidence shows that exosomes are key regulators in cancer cell-to-cell communication. Several reports on Epstein-Barr virus (EBV)-related malignancies demonstrate that latent membrane protein 1 (LMP1) secreted by exosomes derived from EBV- or LMP1-positive cells can promote cancer progres...

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Detalles Bibliográficos
Autores principales: Kobayashi, E., Aga, M., Kondo, S., Whitehurst, C., Yoshizaki, T., Pagano, J. S., Shackelford, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806207/
https://www.ncbi.nlm.nih.gov/pubmed/29435490
http://dx.doi.org/10.1128/mSphere.00030-18