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Junctional trafficking and restoration of retrograde signaling by the cytoplasmic RyR1 domain
The type 1 ryanodine receptor (RyR1) in skeletal muscle is a homotetrameric protein that releases Ca(2+) from the sarcoplasmic reticulum (SR) in response to an “orthograde” signal from the dihydropyridine receptor (DHPR) in the plasma membrane (PM). Additionally, a “retrograde” signal from RyR1 incr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806685/ https://www.ncbi.nlm.nih.gov/pubmed/29284662 http://dx.doi.org/10.1085/jgp.201711879 |