Generation of a monoclonal antibody recognizing the heavily glycosylated CD45 protein and its application on identifying circulating tumor cells

Here, we provide direct evidence that using recombinant proteins expressed in eukaryotic cells as antigen is a practical way to generate monoclonal antibodies (mAbs) against heavily glycosylated proteins. Heavily glycosylated proteins are typically difficult targets for mAb generation, being limited...

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Detalles Bibliográficos
Autores principales: Zhang, Weikai, Li, Zhitao, Wang, Zihua, Yue, Chunyan, Zheng, Hui, Li, Ren, Zhou, Mingxing, Hu, Zhiyuan, Wei, Zewen, Li, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806877/
https://www.ncbi.nlm.nih.gov/pubmed/29425242
http://dx.doi.org/10.1371/journal.pone.0192506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806877/
https://www.ncbi.nlm.nih.gov/pubmed/29425242
http://dx.doi.org/10.1371/journal.pone.0192506

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