Rasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism

Rasa3 is a GTPase activating protein of the GAP1 family which targets R-Ras and Rap1. Although catalytic inactivation or deletion of Rasa3 in mice leads to severe hemorrhages and embryonic lethality, the biological function and cellular location of Rasa3 underlying these defects remains unknown. Her...

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Detalles Bibliográficos
Autores principales: Molina-Ortiz, Patricia, Orban, Tanguy, Martin, Maud, Habets, Audrey, Dequiedt, Franck, Schurmans, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806903/
https://www.ncbi.nlm.nih.gov/pubmed/29381707
http://dx.doi.org/10.1371/journal.pgen.1007195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806903/
https://www.ncbi.nlm.nih.gov/pubmed/29381707
http://dx.doi.org/10.1371/journal.pgen.1007195

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