Metabolic plasticity in synthetic lethal mutants: Viability at higher cost

The most frequent form of pairwise synthetic lethality (SL) in metabolic networks is known as plasticity synthetic lethality. It occurs when the simultaneous inhibition of paired functional and silent metabolic reactions or genes is lethal, while the default of the functional partner is backed up by...

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Detalles Bibliográficos
Autores principales: Massucci, Francesco Alessandro, Sagués, Francesc, Serrano, M. Ángeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806928/
https://www.ncbi.nlm.nih.gov/pubmed/29381693
http://dx.doi.org/10.1371/journal.pcbi.1005949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806928/
https://www.ncbi.nlm.nih.gov/pubmed/29381693
http://dx.doi.org/10.1371/journal.pcbi.1005949

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