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Metabolic plasticity in synthetic lethal mutants: Viability at higher cost
The most frequent form of pairwise synthetic lethality (SL) in metabolic networks is known as plasticity synthetic lethality. It occurs when the simultaneous inhibition of paired functional and silent metabolic reactions or genes is lethal, while the default of the functional partner is backed up by...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806928/ https://www.ncbi.nlm.nih.gov/pubmed/29381693 http://dx.doi.org/10.1371/journal.pcbi.1005949 |