Cargando…

Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma

Glioblastoma is the most malignant and lethal subtype brain tumors with high risk of recurrence and therapeutic resistance. Emerging evidence has indicated that glycogen synthesis kinase 3 (GSK3)β plays oncogenic roles in multiple tumor types; however, the underlying mechanisms remain largely unknow...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Yong, Lei, Tiantian, Du, Suya, Tong, Rongsheng, Wang, Hailian, Yang, Jiao, Huang, Juan, Sun, Minghan, Wang, Yi, Dong, Zhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807039/ https://www.ncbi.nlm.nih.gov/pubmed/29328365 http://dx.doi.org/10.3892/ijo.2018.4237

Ejemplares similares

Acetylation of 53BP1 dictates the DNA double strand break repair pathway
por: Guo, Xiang, et al.
Publicado: (2018)

The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair
por: Salvador Moreno, Naike, et al.
Publicado: (2019)

The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair
por: Moreno, Naike Salvador, et al.
Publicado: (2019)

Tying the loose ends together in DNA double strand break repair with 53BP1
por: Adams, Melissa M, et al.
Publicado: (2006)

HDGFRP3 interaction with 53BP1 promotes DNA double-strand break repair
por: Zhang, Zhen, et al.
Publicado: (2023)

Multifaceted regulation and functions of 53BP1 in NHEJ-mediated DSB repair (Review)
por: Lei, Tiantian, et al.
Publicado: (2022)

Nuclear IGF1R interacts with NuMA and regulates 53BP1-dependent DNA double-strand break repair in colorectal cancer
por: Yang, Chen, et al.
Publicado: (2021)

Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response
por: Thornton, Tina M., et al.
Publicado: (2016)

Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break
por: Lou, Jieqiong, et al.
Publicado: (2020)

Phosphorylation: The Molecular Switch of Double-Strand Break Repair
por: Summers, K. C., et al.
Publicado: (2011)

DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation
por: Ketley, Ruth F., et al.
Publicado: (2022)

Regulation of 53BP1 Protein Stability by RNF8 and RNF168 Is Important for Efficient DNA Double-Strand Break Repair
por: Hu, Yiheng, et al.
Publicado: (2014)

TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks
por: Ma, Jian, et al.
Publicado: (2023)

P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks
por: Schultz, Linda B., et al.
Publicado: (2000)

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks
por: Rother, Magdalena B., et al.
Publicado: (2020)

Multifaceted regulation and functions of YAP/TAZ in tumors
por: Liu, Huirong, et al.
Publicado: (2018)

Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair
por: Shibata, Atsushi, et al.
Publicado: (2020)

Impact of Histone H4 Lysine 20 Methylation on 53BP1 Responses to Chromosomal Double Strand Breaks
por: Hartlerode, Andrea J., et al.
Publicado: (2012)

SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1
por: Dulev, Stanimir, et al.
Publicado: (2014)

TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double‐strand breaks in vertebrate cells
por: Wikiniyadhanee, Rakkreat, et al.
Publicado: (2020)

RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1
por: Watanabe, Kenji, et al.
Publicado: (2009)

PKM2 in carcinogenesis and oncotherapy
por: He, Xia, et al.
Publicado: (2017)

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
por: Chapman, J. Ross, et al.
Publicado: (2013)

Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52
por: Mladenov, Emil, et al.
Publicado: (2020)

ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination
por: Lee, Doohyung, et al.
Publicado: (2022)

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
por: Chapman, J. Ross, et al.
Publicado: (2021)

DNA Double Strand Break Repair in Mitosis Is Suppressed by Phosphorylation of XRCC4
por: Lees-Miller, Susan P.
Publicado: (2014)

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis
por: Gelot, Camille, et al.
Publicado: (2023)

Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment
por: Schipler, Agnes, et al.
Publicado: (2016)

53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks
por: Guirouilh-Barbat, Josée, et al.
Publicado: (2016)

Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability
por: Bueno, Murilo T.D., et al.
Publicado: (2018)

53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function
por: Sundaravinayagam, Devakumar, et al.
Publicado: (2019)

Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells
por: González-Bermúdez, Lourdes, et al.
Publicado: (2022)

PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection
por: Fouquin, Alexis, et al.
Publicado: (2017)

Anti-neoplastic effect of mangiferin on human ovarian adenocarcinoma OVCAR8 cells via the regulation of YAP
por: He, Wenjing, et al.
Publicado: (2019)

Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase
por: Lee, Kyung-Jong, et al.
Publicado: (2016)

Mangiferin induces islet regeneration in aged mice through regulating p16(INK4a)
por: Wang, Hailian, et al.
Publicado: (2018)

Sp1 Upregulation Bolsters the Radioresistance of Glioblastoma Cells by Promoting Double Strand Breaks Repair
por: Liu, Xiongxiong, et al.
Publicado: (2023)

Role of 53BP1 in end protection and DNA synthesis at DNA breaks
por: Paiano, Jacob, et al.
Publicado: (2021)

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
por: Bolderson, Emma, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_82nvnnvrkmd4jfbifft0p48jut