Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

Dysregulated mitophagy has been linked to Parkinson's disease (PD) due to the role of PTEN-induced kinase 1 (PINK1) in mediating depolarization-induced mitophagy in vitro. Elegant mouse reporters have revealed the pervasive nature of basal mitophagy in vivo, yet the role of PINK1 and tissue met...

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Detalles Bibliográficos
Autores principales: McWilliams, Thomas G., Prescott, Alan R., Montava-Garriga, Lambert, Ball, Graeme, Singh, François, Barini, Erica, Muqit, Miratul M.K., Brooks, Simon P., Ganley, Ian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807059/
https://www.ncbi.nlm.nih.gov/pubmed/29337137
http://dx.doi.org/10.1016/j.cmet.2017.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807059/
https://www.ncbi.nlm.nih.gov/pubmed/29337137
http://dx.doi.org/10.1016/j.cmet.2017.12.008

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