Cargando…

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

Dysregulated mitophagy has been linked to Parkinson's disease (PD) due to the role of PTEN-induced kinase 1 (PINK1) in mediating depolarization-induced mitophagy in vitro. Elegant mouse reporters have revealed the pervasive nature of basal mitophagy in vivo, yet the role of PINK1 and tissue met...

Descripción completa

Detalles Bibliográficos
Autores principales:	McWilliams, Thomas G., Prescott, Alan R., Montava-Garriga, Lambert, Ball, Graeme, Singh, François, Barini, Erica, Muqit, Miratul M.K., Brooks, Simon P., Ganley, Ian G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807059/ https://www.ncbi.nlm.nih.gov/pubmed/29337137 http://dx.doi.org/10.1016/j.cmet.2017.12.008

Ejemplares similares

Semi-automated quantitation of mitophagy in cells and tissues
por: Montava-Garriga, Lambert, et al.
Publicado: (2020)

mito-QC illuminates mitophagy and mitochondrial architecture in vivo
por: McWilliams, Thomas G., et al.
Publicado: (2016)

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1
por: Antico, Odetta, et al.
Publicado: (2021)

A comparative map of macroautophagy and mitophagy in the vertebrate eye
por: McWilliams, Thomas G., et al.
Publicado: (2019)

PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease
por: Kazlauskaite, Agne, et al.
Publicado: (2015)

Comment on “mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC”
por: Ganley, Ian G., et al.
Publicado: (2021)

Loss of iron triggers PINK1/Parkin-independent mitophagy
por: Allen, George F G, et al.
Publicado: (2013)

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1
por: Barini, Erica, et al.
Publicado: (2018)

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations
por: Kumar, Atul, et al.
Publicado: (2017)

DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion
por: Long, Maeve, et al.
Publicado: (2022)

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo
por: McWilliams, Thomas G., et al.
Publicado: (2018)

Fine-tune TMEM11 to unleash basal mitophagy
por: McWilliams, Thomas G.
Publicado: (2023)

Ubiquitin and Parkinson's disease through the looking glass of genetics
por: Walden, Helen, et al.
Publicado: (2017)

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin
por: Lee, Juliette J., et al.
Publicado: (2018)

Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway
por: Amadoro, Giuseppina, et al.
Publicado: (2014)

Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice
por: Singh, Francois, et al.
Publicado: (2021)

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser(65)
por: Kazlauskaite, Agne, et al.
Publicado: (2014)

Whole proteome copy number dataset in primary mouse cortical neurons
por: Antico, Odetta, et al.
Publicado: (2023)

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation
por: Kazlauskaite, Agne, et al.
Publicado: (2015)

Mammalian mitophagy – from in vitro molecules to in vivo models
por: Rodger, Catherine E., et al.
Publicado: (2017)

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
por: Ashrafi, Ghazaleh, et al.
Publicado: (2014)

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1
por: Lai, Yu‐Chiang, et al.
Publicado: (2015)

PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage
por: Lambourne, Olivia A., et al.
Publicado: (2023)

Role of Pink1-mediated mitophagy in adenomyosis
por: Chen, Minmin, et al.
Publicado: (2023)

Mitophagy and Parkinson's disease: The PINK1–parkin link()
por: Deas, Emma, et al.
Publicado: (2011)

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations
por: Woodroof, Helen I., et al.
Publicado: (2011)

PINK1-induced mitophagy promotes neuroprotection in Huntington's disease
por: Khalil, B, et al.
Publicado: (2015)

PINK1 mediates spinal cord mitophagy in neuropathic pain
por: Yi, Min-Hee, et al.
Publicado: (2019)

PINK1‐mediated mitophagy maintains pluripotency through optineurin
por: Wang, Chaoqun, et al.
Publicado: (2021)

PINK1: From Parkinson’s disease to mitophagy and back again
por: O’Callaghan, Benjamin, et al.
Publicado: (2023)

Strengthening the link between mitophagy and Parkinson’s disease
por: Ganley, Ian G
Publicado: (2022)

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
por: Kondapalli, Chandana, et al.
Publicado: (2012)

PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes
por: Kubli, Dieter A., et al.
Publicado: (2015)

Diversity of mitophagy pathways at a glance
por: Ganley, Ian G., et al.
Publicado: (2022)

A meeting of minds: Overcoming roadblocks in the development of therapies for neurodegenerative disorders
por: Muqit, Miratul M K, et al.
Publicado: (2009)

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications
por: Durcan, Thomas M., et al.
Publicado: (2015)

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
por: Lazarou, Michael, et al.
Publicado: (2015)

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila
por: Cornelissen, Tom, et al.
Publicado: (2018)

PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses
por: Tsubouchi, Kazuya, et al.
Publicado: (2018)

PINK1 mediates spinal cord mitophagy in neuropathic pain [Corrigendum]
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ohqpfamf63sbf4v0f4fco7hutk