Altered DNA methylation indicates an oscillatory flow mediated epithelial-to-mesenchymal transition signature in ascending aorta of patients with bicuspid aortic valve

Disturbed flow has been suggested to contribute to aneurysm susceptibility in bicuspid aortic valve (BAV) patients. Lately, flow has emerged as an important modulator of DNA methylation. Hear we combined global methylation analysis with in vitro studies of flow-sensitive methylation to identify biol...

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Detalles Bibliográficos
Autores principales: Björck, Hanna M., Du, Lei, Pulignani, Silvia, Paloschi, Valentina, Lundströmer, Karin, Kostina, Alexandra S., Österholm, Cecilia, Malashicheva, Anna, Kostareva, Anna, Evangelista, Arturo, Teixidó-Tura, Gisela, Maleki, Shohreh, Franco-Cereceda, Anders, Eriksson, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807320/
https://www.ncbi.nlm.nih.gov/pubmed/29426841
http://dx.doi.org/10.1038/s41598-018-20642-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807320/
https://www.ncbi.nlm.nih.gov/pubmed/29426841
http://dx.doi.org/10.1038/s41598-018-20642-4

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