Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation

Ultraconserved (uc) RNAs, a class of long non-coding RNAs (lncRNAs), are conserved across humans, mice, and rats, but the physiological significance and pathological role of ucRNAs is largely unknown. Here we show that uc.372 is upregulated in the livers of db/db mice, HFD-fed mice, and NAFLD patien...

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Detalles Bibliográficos
Autores principales: Guo, Jun, Fang, Weiwei, Sun, Libo, Lu, Yonggang, Dou, Lin, Huang, Xiuqing, Tang, Weiqing, Yu, Liqing, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807361/
https://www.ncbi.nlm.nih.gov/pubmed/29426937
http://dx.doi.org/10.1038/s41467-018-03072-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807361/
https://www.ncbi.nlm.nih.gov/pubmed/29426937
http://dx.doi.org/10.1038/s41467-018-03072-8

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