TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) produces the second messenger cGAMP, which subsequently initiates downstr...

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Detalles Bibliográficos
Autores principales: Seo, Gil Ju, Kim, Charlotte, Shin, Woo-Jin, Sklan, Ella H., Eoh, Hyungjin, Jung, Jae U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807518/
https://www.ncbi.nlm.nih.gov/pubmed/29426904
http://dx.doi.org/10.1038/s41467-018-02936-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807518/
https://www.ncbi.nlm.nih.gov/pubmed/29426904
http://dx.doi.org/10.1038/s41467-018-02936-3

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