Incorporation of a skeletal muscle-specific enhancer in the regulatory region of Igf1 upregulates IGF1 expression and induces skeletal muscle hypertrophy

In this study, we upregulated insulin-like growth factor-1 (IGF1) expression specifically in skeletal muscle by engineering an enhancer into its non-coding regions and verified the expected phenotype in a mouse model. To select an appropriate site for introducing a skeletal muscle-specific myosin li...

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Detalles Bibliográficos
Autores principales: Zou, Yunlong, Dong, Yanjun, Meng, Qingyong, Zhao, Yaofeng, Li, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807547/
https://www.ncbi.nlm.nih.gov/pubmed/29426944
http://dx.doi.org/10.1038/s41598-018-21122-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807547/
https://www.ncbi.nlm.nih.gov/pubmed/29426944
http://dx.doi.org/10.1038/s41598-018-21122-5

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